1-(Chlorocarbonyl)cyclopropyl acetate → HCID 66867282, compound

HRID 2094164Notes

Reaction equation

HRID 2094164 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:20]=4[O:26][CH2:27][CH:28]4[CH2:30][CH2:29]4)[C:13]=3[NH:12][CH:11]=2)=[O:9])[CH2:3][CH2:2]1.Cl[C:32]([C:34]1([O:37]C(=O)C)[CH2:36][CH2:35]1)=[O:33]>>[OH:37][C:34]1([C:32]([N:1]2[CH2:2][CH2:3][CH:4]([NH:7][C:8]([C:10]3[C:14]4[N:15]=[CH:16][N:17]=[C:18]([C:19]5[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:20]=5[O:26][CH2:27][CH:28]5[CH2:29][CH2:30]5)[C:13]=4[NH:12][CH:11]=3)=[O:9])[CH2:5][CH2:6]2)=[O:33])[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 143196381-(Chlorocarbonyl)cyclopropyl acetateHCID 66865891HCID 66865891, compound

Product 1

HCID 66867282HCID 66867282, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-methyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide (example A171) and acetic acid 1-chlorocarbonyl-cyclopropyl ester the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-fd2fcdf8b00343f7a798a301b9b3fbd5
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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