1-(4-Aminopiperidin-1-yl)ethan-1-one → HCID 66867164, compound

HRID 2094180Notes

Reaction equation

HRID 2094180 reaction equation
[C:1]([C:4]1[C:5]([CH3:27])=[CH:6][C:7]([O:22][CH2:23][CH:24]2[CH2:26][CH2:25]2)=[C:8]([C:10]2[C:11]3[NH:18][CH:17]=[C:16]([C:19]([OH:21])=O)[C:12]=3[N:13]=[CH:14][N:15]=2)[CH:9]=1)(=[O:3])[CH3:2].[NH2:28][CH:29]1[CH2:34][CH2:33][N:32]([C:35](=[O:37])[CH3:36])[CH2:31][CH2:30]1>>[C:35]([N:32]1[CH2:33][CH2:34][CH:29]([NH:28][C:19]([C:16]2[C:12]3[N:13]=[CH:14][N:15]=[C:10]([C:8]4[CH:9]=[C:4]([C:1](=[O:3])[CH3:2])[C:5]([CH3:27])=[CH:6][C:7]=4[O:22][CH2:23][CH:24]4[CH2:25][CH2:26]4)[C:11]=3[NH:18][CH:17]=2)=[O:21])[CH2:30][CH2:31]1)(=[O:37])[CH3:36]

Participants

3

Reactant 2

HCID 49624771-(4-Aminopiperidin-1-yl)ethan-1-oneHCID 66866718HCID 66866718, compound

Product 1

HCID 66867164HCID 66867164, compound

Procedure

Starting from 4-(5-acetyl-2-cyclopropylmethoxy-4-methyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A82) and 1-(4-amino-piperidin-1-yl)-ethanone (A191) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-ae5ba50c0ee1447f877ab15b38013329
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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