4-(5-Cyclopropylmethoxy-1,3-benzodioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178523774, compound

HRID 2094182Notes

Reaction equation

HRID 2094182 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]3[O:10][CH2:11][O:12][C:8]=3[C:7]=2[C:15]2[C:16]3[NH:23][CH:22]=[C:21]([C:24]([OH:26])=O)[C:17]=3[N:18]=[CH:19][N:20]=2)[CH2:3][CH2:2]1.[CH:27]1([NH:30][C:31]([C@H:33]2[CH2:38][CH2:37][C@H:36]([NH:39]C(=O)O)[CH2:35][CH2:34]2)=[O:32])[CH2:29][CH2:28]1>>[CH:27]1([NH:30][C:31]([C@H:33]2[CH2:38][CH2:37][C@H:36]([NH:39][C:24]([C:21]3[C:17]4[N:18]=[CH:19][N:20]=[C:15]([C:7]5[C:8]6[O:12][CH2:11][O:10][C:9]=6[CH:13]=[CH:14][C:6]=5[O:5][CH2:4][CH:1]5[CH2:2][CH2:3]5)[C:16]=4[NH:23][CH:22]=3)=[O:26])[CH2:35][CH2:34]2)=[O:32])[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 668660154-(5-Cyclopropylmethoxy-1,3-benzodioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178526091HCID 178526091, compound

Product 1

HCID 178523774HCID 178523774, compound

Procedure

Starting from 4-(5-cyclopropylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A67) and trans-(4-cyclopropylcarbamoyl-cyclohexyl)-carbamic acid tart-butyl ester (A195) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-9a6851e746534569983e7b95ac21c4ba
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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