4-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178488989, compound

HRID 2094183Notes

Reaction equation

HRID 2094183 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:7]=2[C:14]2[C:15]3[NH:22][CH:21]=[C:20]([C:23]([OH:25])=O)[C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:3][CH2:2]1.C(OC(=O)[NH:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([C:39](=[O:44])[NH:40][CH:41]2[CH2:43][CH2:42]2)[CH2:35][CH2:34]1)(C)(C)C>>[CH:41]1([NH:40][C:39]([C@H:36]2[CH2:37][CH2:38][C@H:33]([NH:32][C:23]([C:20]3[C:16]4[N:17]=[CH:18][N:19]=[C:14]([C:7]5[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[CH:11][C:6]=5[O:5][CH2:4][CH:1]5[CH2:2][CH2:3]5)[C:15]=4[NH:22][CH:21]=3)=[O:25])[CH2:34][CH2:35]2)=[O:44])[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 668660964-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178453958HCID 178453958, compound

Product 1

HCID 178488989HCID 178488989, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A73) and trans-(4-cyclopropylcarbamoyl-cyclohexyl)-carbamic acid tert-butyl ester (A195) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-df16668123f94934b26eec29ca9f6fd4
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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