4-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178496022, compound

HRID 2094184Notes

Reaction equation

HRID 2094184 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:7]=2[C:14]2[C:15]3[NH:22][CH:21]=[C:20]([C:23]([OH:25])=O)[C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:3][CH2:2]1.Cl.[CH3:27][O:28][CH2:29][CH2:30][NH:31][C:32]([C@H:34]1[CH2:39][CH2:38][C@H:37]([NH2:40])[CH2:36][CH2:35]1)=[O:33]>>[CH3:27][O:28][CH2:29][CH2:30][NH:31][C:32]([C@H:34]1[CH2:35][CH2:36][C@H:37]([NH:40][C:23]([C:20]2[C:16]3[N:17]=[CH:18][N:19]=[C:14]([C:7]4[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[CH:11][C:6]=4[O:5][CH2:4][CH:1]4[CH2:3][CH2:2]4)[C:15]=3[NH:22][CH:21]=2)=[O:25])[CH2:38][CH2:39]1)=[O:33]

Participants

3

Reactant 2

HCID 668660964-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178496021HCID 178496021, compound

Product 1

HCID 178496022HCID 178496022, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A73) and trans-4-amino-cyclohexanecarboxylic acid (2-methoxy-ethyl)-amide hydrochloride (A196) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-548f02d33b56466ca74e7cc1567a8569
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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