4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178523773, compound

HRID 2094185Notes

Reaction equation

HRID 2094185 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=2[C:13]2[C:14]3[NH:21][CH:20]=[C:19]([C:22](O)=[O:23])[C:15]=3[N:16]=[CH:17][N:18]=2)[CH2:3][CH2:2]1.C(OC(=O)[NH:31][C@H:32]1[CH2:37][CH2:36][C@H:35]([C:38](=[O:43])[NH:39][CH:40]2[CH2:42][CH2:41]2)[CH2:34][CH2:33]1)(C)(C)C>>[CH:40]1([NH:39][C:38]([C@H:35]2[CH2:36][CH2:37][C@H:32]([NH:31][C:22]([C:19]3[C:15]4[N:16]=[CH:17][N:18]=[C:13]([C:7]5[CH:8]=[C:9]([F:12])[CH:10]=[CH:11][C:6]=5[O:5][CH2:4][CH:1]5[CH2:3][CH2:2]5)[C:14]=4[NH:21][CH:20]=3)=[O:23])[CH2:33][CH2:34]2)=[O:43])[CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 668679844-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178453958HCID 178453958, compound

Product 1

HCID 178523773HCID 178523773, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A77) and trans-(4-cyclopropylcarbamoyl-cyclohexyl)-carbamic acid tert-butyl ester (A195) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-dcc6f850c7e245f495d01d4363fbf02f
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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