4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178496023, compound

HRID 2094186Notes

Reaction equation

HRID 2094186 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=2[C:13]2[C:14]3[NH:21][CH:20]=[C:19]([C:22](O)=[O:23])[C:15]=3[N:16]=[CH:17][N:18]=2)[CH2:3][CH2:2]1.Cl.[CH3:26][O:27][CH2:28][CH2:29][NH:30][C:31]([C@H:33]1[CH2:38][CH2:37][C@H:36]([NH2:39])[CH2:35][CH2:34]1)=[O:32]>>[CH3:26][O:27][CH2:28][CH2:29][NH:30][C:31]([C@H:33]1[CH2:34][CH2:35][C@H:36]([NH:39][C:22]([C:19]2[C:15]3[N:16]=[CH:17][N:18]=[C:13]([C:7]4[CH:8]=[C:9]([F:12])[CH:10]=[CH:11][C:6]=4[O:5][CH2:4][CH:1]4[CH2:2][CH2:3]4)[C:14]=3[NH:21][CH:20]=2)=[O:23])[CH2:37][CH2:38]1)=[O:32]

Participants

3

Reactant 2

HCID 668679844-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178496021HCID 178496021, compound

Product 1

HCID 178496023HCID 178496023, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A77) and trans-4-amino-cyclohexanecarboxylic acid (2-methoxy-ethyl)-amide hydrochloride (A196) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-1008156ba7bf466284f26b88a65f7083
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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