4-(5-Cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178496025, compound

HRID 2094187Notes

Reaction equation

HRID 2094187 reaction equation
[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][C:10]3[O:11][CH2:12][O:13][C:9]=3[C:8]=2[C:16]2[C:17]3[NH:24][CH:23]=[C:22]([C:25]([OH:27])=O)[C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:4][CH2:3][CH2:2]1.Cl.[CH3:29][O:30][CH2:31][CH2:32][NH:33][C:34]([C@H:36]1[CH2:41][CH2:40][C@H:39]([NH2:42])[CH2:38][CH2:37]1)=[O:35]>>[CH3:29][O:30][CH2:31][CH2:32][NH:33][C:34]([C@H:36]1[CH2:37][CH2:38][C@H:39]([NH:42][C:25]([C:22]2[C:18]3[N:19]=[CH:20][N:21]=[C:16]([C:8]4[C:9]5[O:13][CH2:12][O:11][C:10]=5[CH:14]=[CH:15][C:7]=4[O:6][CH2:5][CH:1]4[CH2:4][CH2:3][CH2:2]4)[C:17]=3[NH:24][CH:23]=2)=[O:27])[CH2:40][CH2:41]1)=[O:35]

Participants

3

Reactant 2

HCID 668668184-(5-Cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178496021HCID 178496021, compound

Product 1

HCID 178496025HCID 178496025, compound

Procedure

Starting 4-(5-cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A68) and trans-4-amino-cyclohexanecarboxylic acid (2-methoxy-ethyl)-amide hydrochloride (A196) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-df97bd8d656b41189ec0d8c1b2816ad7
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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