4-(5-Cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid → HCID 178523775, compound

HRID 2094188Notes

Reaction equation

HRID 2094188 reaction equation
[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][C:10]3[O:11][CH2:12][O:13][C:9]=3[C:8]=2[C:16]2[C:17]3[NH:24][CH:23]=[C:22]([C:25](O)=[O:26])[C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:4][CH2:3][CH2:2]1.C(OC(=O)[NH:34][C@H:35]1[CH2:40][CH2:39][C@H:38]([C:41](=[O:46])[NH:42][CH:43]2[CH2:45][CH2:44]2)[CH2:37][CH2:36]1)(C)(C)C>>[CH:43]1([NH:42][C:41]([C@H:38]2[CH2:39][CH2:40][C@H:35]([NH:34][C:25]([C:22]3[C:18]4[N:19]=[CH:20][N:21]=[C:16]([C:8]5[C:9]6[O:13][CH2:12][O:11][C:10]=6[CH:14]=[CH:15][C:7]=5[O:6][CH2:5][CH:1]5[CH2:2][CH2:3][CH2:4]5)[C:17]=4[NH:24][CH:23]=3)=[O:26])[CH2:36][CH2:37]2)=[O:46])[CH2:45][CH2:44]1

Participants

3

Reactant 2

HCID 668668184-(5-Cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acidHCID 178453958HCID 178453958, compound

Product 1

HCID 178523775HCID 178523775, compound

Procedure

Starting from 4-(5-cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A68) and trans-(4-cyclopropylcarbamoyl-cyclohexyl)-carbamic acid tert-butyl ester (A195) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-5e68069ced99467584d00759fe88db43
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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