Methoxyacetyl chloride → HCID 66866635, compound

HRID 2094192Notes

Reaction equation

Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([F:26])[C:23]([O:27][CH:28]([F:30])[F:29])=[CH:22][C:21]=4[O:31][CH2:32][CH:33]4[CH2:35][CH2:34]4)[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1.[CH3:36][O:37][CH2:38][C:39](Cl)=[O:40]>>[CH3:36][O:37][CH2:38][C:39]([N:2]1[CH2:3][CH2:4][CH:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([F:26])[C:23]([O:27][CH:28]([F:30])[F:29])=[CH:22][C:21]=4[O:31][CH2:32][CH:33]4[CH2:34][CH2:35]4)[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:6][CH2:7]1)=[O:40]

Participants

Reactant 2

HCID 96623Methoxyacetyl chloride

HCID 66867611HCID 66867611, compound

Product 1

HCID 66866635HCID 66866635, compound

Procedure

Starting from 4-[2-cyclopropylmethoxy-4-(1,1-difluoro-methoxy)-5-fluoro-phenyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide hydrochloride (example A189) and methoxy-acetyl chloride the title compound is obtained as colorless solid

Sources & evidence

ORD record: ord-073064b7cccc42b2b8dfca8568c20676
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445501B2

Reaction notes

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