2,6-Diisopropylphenyl isocyanate → HCID 66778235, compound

Participants

Reaction Conditions

Reaction Steps

150 μl (0.71 mmol, 1.2 eq.) of 2,6-diisopropylphenylisocyanate are added to a solution of 130 mg (0.59 mmol, 1 eq.) of 1-(pyridin-3-ylamino)-cyclohexanecarboxylic acid amide in 5 ml of toluene. The reaction medium is stirred at 200° C. for 1 hour 30 minutes under microwave irradiation. The toluene is evaporated off and the residue is purified on silica gel (heptane and then with an increasing percentage of ethyl acetate). 1-Pyridin-3-yl-1,3-diaza-spiro[4.5]decane-2,4-dione is obtained in the form of a white solid. Melting point=264-266° C.

Provenance & Evidence