1-Propanol → HCID 67071817, compound

Participants

Reaction Steps

Under ice-cooling, 1-propanol (60 μL, 0.80 mmol), n-tributylphosphine (100 μL, 0.40 mmol) and 1,1′-(azodicarbonyl)dipiperidine (98 mg, 0.39 mmol) were added to a suspension of 2-aminocarbonylamino-6-hydroxyindole-3-carboxamide (Compound No.2-1, 47 mg, 0.20 mmol) in anhydrous tetrahydrofuran (2 mL) and stirred for 2.5 hours. Moreover the whole was stirred overnight at room temperature, and stirred at 50° C. for 7 hours. The reaction solution was purified by silica gel column chromatography to give the title compound (7 mg) as a green solid (13%).

Provenance & Evidence