HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 44609577, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67071861 | HCID 67071861 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44609577 | HCID 44609577 | 47.6% |
Reaction Steps
The solution of 2-aminocarbonylamino-6-(4-aminophenyloxy)indole-3-carboxamide (Compound No.5-1, 40 mg, 0.12 mmol), acetic acid (8 μL, 0.14 mmol), N,N-diisopropylethylamine (46 μL, 0.26 mmol) and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (48 mg, 0.13 mmol) in anhydrous N,N-dimethylformamide (1 mL) was stirred overnight at room temperature. Water (10 mL) was added to the reaction solution, and the precipitated solid was filtered off and washed with water (10 mL). The solid was dried at 40° C. under reduced pressure to give the title compound (21 mg) as a purple solid (46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445529B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-37749bfdf1274fe58105149fcf35d5cb |
| Source note | uspto-grants-2013_05 |