Acetonitrile → HCID 24805263, compound

HRID 2094218Notes

Reaction equation

HRID 2094218 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:13]([C:19]([NH:21][NH2:22])=O)=[N:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[C:23]([F:26])([F:25])[F:24].COC(OC)OC.[C:34](#N)C.[CH3:37][N:38]1[C:42]([NH2:43])=[CH:41][CH:40]=[N:39]1>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:13]([C:19]3[N:43]([C:42]4[N:38]([CH3:37])[N:39]=[CH:40][CH:41]=4)[CH:34]=[N:22][N:21]=3)=[N:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[C:23]([F:26])([F:25])[F:24]

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 9005Trimethyl orthoformateHCID 1369272-Methyl-2H-pyrazol-3-ylamineHCID 59216810HCID 59216810, compound

Product 1

HCID 24805263HCID 24805263, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared according to general Method B. using 4-Chloro-N-(5-chloro-2-hydrazinocarbonyl-pyridin-3-yl)-3-trifluoromethyl-benzenesulfonamide (100 mg, 0.234 mmol), trimethylorthoformate (80 mg, 0.75 mmol), acetonitrile (2 mL), 2-Methyl-2H-pyrazol-3-ylamine (48 mg, 0.50 mmol) and acetic acid (1.0 mL). MS (ES) [M+H]+ expected 518.0. found 518.0.

Sources & evidence

ORD record
ord-4cafb379c841470dad58edc621a885b0
Source dataset
uspto-grants-2013_05
Patent number
US08445518B2

Reaction notes

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