HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178462089, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | 3-Chloro-4-(tetrahydro-pyrimidin-2-on-1-yl)-benzoic acid | HCID 64319530 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178462089 | HCID 178462089 | — |
Reaction Steps
Prepared analogously to Example 1f from 3-chloro-4-(tetrahydro-pyrimidin-2-on-1-yl)-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamine, TBTU and NMM in DMF, then pouring into ice water, adding conc. ammonia solution, filtering, washing with water and purifying by chromatography on silica gel (eluting gradient ethyl acetate/(methanol/conc. ammonia solution 19:1)=98:2->90:10) with subsequent filtration through activated charcoal, trituration with ether and drying in the drying pistol at 70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445525B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-bc4a04a0d01c4c0d8c486b3429b6b3ce |
| Source note | uspto-grants-2013_05 |