HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl 4-(3-chloro-propyl-sulphonyl-amino)-3-methyl-benzoate | HCID 43654282 | — |
| Reactant | Potassium tertbutoxide | HCID 50987170 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate | HCID 67048536 | — |
Reaction Steps
370 mg (0.85 mmol) 70% methyl 4-(3-chloropropane-sulphonylamino)-3-methyl-benzoate dissolved in 26 ml DMF are combined with 275 mg (2.45 mmol) potassium-tert.-butoxide and stirred for 16 hours at ambient temperature. The reaction mixture is combined with water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate, evaporated down i. vac. and the residue is purified by chromatography on silica gel (eluant: dichloromethane/isopropanol 98:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445525B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-a88fc949b2284269a6e7470c66b343ed |
| Source note | uspto-grants-2013_05 |