反应详情

170 mg (0.63 mmol) methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate are stirred in 2 ml of ethanol at ambient temperature for 3 hours with 0.6 ml of 2-molar sodium hydroxide solution. Then the reaction solution is evaporated down i. vac., combined with water and 0.6 ml 2-molar hydrochloric acid and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate, evaporated down i. vac. and the residue is further reacted without any more purification.

1. customThen the reaction solution is evaporated down i
2. extractionextracted with ethyl acetate
3. dry with materialThe combined organic phases are dried over sodium sulphate
4. customevaporated down i
5. customand the residue is further reacted without any more purification