HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-(1H-tetrazol-5-yl)-propyl]-3-methyl-4-(morpholin-3-on-4-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl-4-(3-oxomorpholin-4-yl)benzoic acid | HCID 67048526 | — |
| Reactant | (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-(1H-tetrazol-5-yl)propylamine | HCID 178511819 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-(1H-tetrazol-5-yl)-propyl]-3-methyl-4-(morpholin-3-on-4-yl)-benzamide | HCID 178427158 | — |
Reaction Steps
Prepared analogously to Example 1f from 3-methyl-4-(morpholin-3-on-4-yl)-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-(1H-tetrazol-5-yl)-propylamine, TBTU and DIPEA in THF with subsequent purification by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445525B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-41e1b3c3a81a4f3da05ff524a1c0a123 |
| Source note | uspto-grants-2013_05 |