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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2094292Generated: November 4, 2026

Trifluoroacetic acid → (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamine

https://huagongshe.com/reaction/2094292

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 178495124HCID 178495124—
SolventDichloromethaneHCID 6344—
Product(S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamineHCID 178495121—

Reaction Steps

Prepared analogously to Example 1g from (1S)—N-Boc-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxy-propylamine and TFA in dichloromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445525B2
Source datasetuspto-grants-2013_05
ORD IDord-bd04a61470674ad5bb029fe1b83bab34
Source noteuspto-grants-2013_05