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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2094312Generated: November 2, 2026

4-Methylmorpholine → N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-benzamide

https://huagongshe.com/reaction/2094312

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylmorpholineHCID 7972—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant3-Methyl-4-(5-oxo-[1,4]oxazepan-4-yl)benzoic acidHCID 67048325—
ReactantHCID 178495727HCID 178495727—
SolventDimethylformamideHCID 6228—
ProductN-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-benzamideHCID 178495745—

Reaction Steps

Prepared analogously to Example 1f from 3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-benzoic acid, (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethylamine, TBTU and NMM in DMF with subsequent purification by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445525B2
Source datasetuspto-grants-2013_05
ORD IDord-34e09477f3c94f76bab63e61741b9d4e
Source noteuspto-grants-2013_05