HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Chloro-4-(2-hydroxy-1-methyl-ethylamino)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Aminopropanol | HCID 5126 | — |
| Reactant | 3-Chloro-4-fluorobenzonitrile | HCID 145525 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-Chloro-4-(2-hydroxy-1-methyl-ethylamino)-benzonitrile | HCID 63094284 | — |
Reaction Steps
4.00 g (25.7 mmol) 3-chloro-4-fluoro-benzonitrile are heated to 60° C. in 20 ml DMSO with 8.00 g (106.5 mmol) 2-amino-1-propanol with stirring for 2 hours. Then the reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are washed with water and sat. sodium chloride solution, dried over sodium sulphate and evaporated down i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445525B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-68bc354c1ee14f33bb585288027ecd35 |
| Source note | uspto-grants-2013_05 |