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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2094336Generated: November 2, 2026

Dimethylformamide → Ethyl 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoate

https://huagongshe.com/reaction/2094336

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantThionyl ChlorideHCID 24386—
ReactantEthyl 3-chloro-4-[2-(hydroxycarbonylmethoxy)-1-methyl-ethylamino]-benzoateHCID 67048486—
SolventDichloromethaneHCID 6344—
ProductEthyl 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoateHCID 67049237—

Reaction Steps

Prepared analogously to Example 41c from ethyl 3-chloro-4-[2-(hydroxycarbonyl-methoxy)-1-methyl-ethylamino]-benzoate and thionyl chloride with DMF in dichloromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445525B2
Source datasetuspto-grants-2013_05
ORD IDord-131017e184784e7487ff55e96cb0295c
Source noteuspto-grants-2013_05