Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Isonicotinic Acid | HCID 5922 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 2-Amino-5-tert-butylphenol | HCID 15294169 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 58148107 | HCID 58148107 | 51.9% |
Reaction Steps
A mixture of 1.44 g of 2-amino-5-tert-butylphenol, 1.07 g of isonicotinic acid, 2.17 g of WSC and 15 ml of pyridine was stirred while heating at 80° C. for five hours. The reaction mixture was cooled to room temperature, and then water was poured. Precipitated solid was filtered and washed with water and diethyl ether to give 1.22 g of N-(4-tert-butyl-2-hydroxyphenyl)isonicotinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08445522B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-300a561114fb41a38f966e0c12e568e3 |
|---|
| Source note | uspto-grants-2013_05 |
|---|
