참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 3-iodopyridine-4-carboxylate | HCID 2762504 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Iodopyridine-4-carboxylic acid | HCID 619275 | 94.4% |
반응 단계
Water was added to 3.20 g of sodium hydroxide to make 30 ml of aqueous solution in total. To the solution, 5.83 g of 3-iodo-isonicotinic acid methyl ester (U.S. Pat. No. 6,277,871B1, O'Conner et al.) was added. The mixture solution was stirred while heating at 60° C. for three hours. The reaction mixture was cooled in ice, to which concentrated hydrochloric acid was added to adjust pH to 2-3. Precipitates were collected by filtration and dried under reduced pressure to give 5.21 g of 3-iodo-isonicotinic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08445522B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_05 |
|---|
| ORD ID | ord-9aed82ca22544ff3ac021885d2845c9f |
|---|
| 출처 메모 | uspto-grants-2013_05 |
|---|
