4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 1-(4-(4-(4-Aminophenyl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea

HRID 2094600Notes

Reaction equation

HRID 2094600 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:23][CH3:24])=[O:22])=[CH:16][CH:15]=2)[N:3]=1.CC1(C)C(C)(C)OB([C:33]2[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=2)O1>>[NH2:37][C:36]1[CH:38]=[CH:39][C:33]([C:2]2[N:7]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:5]=[C:4]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:23][CH3:24])=[O:22])=[CH:16][CH:15]=3)[N:3]=2)=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 866365231-(4-(4-Chloro-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Product 1

HCID 674385231-(4-(4-(4-Aminophenyl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-methylureaYield 45%

Procedure

The title compound was prepared by following the procedure of Example 462 step 4 using 1-(4-(4-chloro-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. Yield 2 g, 45% yield.

Sources & evidence

ORD record
ord-7299fa9fd5e84e9faae698b8f568e5e7
Source dataset
uspto-grants-2013_05
Patent number
US08445486B2

Reaction notes

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