3-Methyl-1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea → 1-(4-(4-Chloro-6-(3,5-dimethylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea

HRID 2094604Notes

Reaction equation

HRID 2094604 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([N:9]2[CH:14]([CH3:15])[CH2:13][O:12][CH2:11][CH:10]2[CH3:16])[N:3]=1.[CH3:17][NH:18][C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25](B2OC(C)(C)C(C)(C)O2)=[CH:24][CH:23]=1)=[O:20]>>[Cl:8][C:6]1[N:5]=[C:4]([N:9]2[CH:14]([CH3:15])[CH2:13][O:12][CH2:11][CH:10]2[CH3:16])[N:3]=[C:2]([C:25]2[CH:24]=[CH:23][C:22]([NH:21][C:19]([NH:18][CH3:17])=[O:20])=[CH:27][CH:26]=2)[N:7]=1

Participants

3

Reactant 2

HCID 177502733-Methyl-1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ureaHCID 866365254-(4,6-Dichloro-1,3,5-triazin-2-yl)-3,5-dimethylmorpholine

Product 1

HCID 866365241-(4-(4-Chloro-6-(3,5-dimethylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylureaYield 16%

Procedure

The title compound was prepared by following the procedure of example 462 step 4 using 4-(4,6-dichloro-1,3,5-triazin-2-yl)-3,5-dimethylmorpholine and 1-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea. Yield 1.15 g, 16% yield.

Sources & evidence

ORD record
ord-aada94cfc15d43b4a103b2546436fd2a
Source dataset
uspto-grants-2013_05
Patent number
US08445486B2

Reaction notes

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