Water → HCID 178420349, compound

Participants

Reaction Steps

2.0 g (6.8 mmol) of trans-1-amino-4-dibenzylaminocyclohexane (see Ex. 2) is dissolved in 50 mL DMF and stirred for 48 h at RT with 1.6 g (7 mmol) of 1,5-dibromopentane and 2 g of potassium carbonate. The mixture is cooled, combined with water, extracted twice with 100 mL dichloromethane, dried and the solvent is eliminated in vacuo. The residue is purified through a column (approx. 100 mL silica gel, approx. 500 mL ethyl acetate 80/methanol 20+1% conc. ammonia). The desired fractions are evaporated down in vacuo and crystallised from petroleum ether. Yield: 1.2 g (49%).

Provenance & Evidence