Water → 3-Acetoxy-4-trifluoromethyl-benzoic acid

HRID 2094707Notes

Reaction equation

HRID 2094707 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[C:5]([OH:7])=[O:6].O.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([O:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:12])([F:13])[F:14])[C:5]([OH:7])=[O:6])(=[O:18])[CH3:17]

Participants

4

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 109436363-hydroxy-4-(trifluoromethyl)benzoic Acid

Product 1

HCID 236167943-Acetoxy-4-trifluoromethyl-benzoic acid

Procedure

3.5 g (17 mmol) of 3-hydroxy-4-trifluoromethyl-benzoic acid (prepared as described in WO 2006/128184) were dissolved in 35 ml of acetic acid anhydride and heated to reflux for 3 h. 60 ml of water were added and heating to reflux was continued for 10 min. After cooling and stirring overnight, the formed precipitate was collected by suction and dried to give 3.0 g of the title compound.

Workup

  1. temperatureheated
  2. temperatureto reflux for 3 h
  3. temperatureheating
  4. temperatureto reflux
  5. temperatureAfter cooling
  6. customthe formed precipitate was collected by suction
  7. customdried

Sources & evidence

ORD record
ord-957a9001908f4cabab4b9c44098245c7
Source dataset
uspto-grants-2013_05
Patent number
US08445530B2

Reaction notes

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