HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-Bromo-5-fluoro-4-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-bromo-5-fluoro-4-methoxybenzoate | HCID 67076673 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Bromo-5-fluoro-4-methoxybenzoic acid | HCID 11807033 | 52.8% |
Reaction Steps
5.8 g of the product obtained in step 2 were dissolved in 100 ml of a mixture of THF and water (9:1), 1.06 g (44.1 mmol) of lithium hydroxide were added and the mixture was stirred for 3 days. The solvent was evaporated and the residue was purified by preparative RP HPLC (water/ACN gradient). 2.9 g of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445530B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-2168b25723cf48a7a054239935a97829 |
| Source note | uspto-grants-2013_05 |