HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Bromo-2-chloronicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 2-Amino-5-bromopyridine-3-carbonitrile | HCID 24229199 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-2-chloronicotinonitrile | HCID 21948269 | 70% |
Reaction Steps
Compound 2 was dissolved in conc. HCl at 0° C., to which 1.1 equivalent of NaNO2 in H2O was added dropwise. Precipitation was formed. The white solid was filtered off, which gave the title compound 3. Overall yield was 70%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445681B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-ed7086d38ab34126a973a71028211990 |
| Source note | uspto-grants-2013_05 |