反应详情

Sodium cyanate (1.7 g, 0.02 mol) was dissolved in water (17 ml) at room temperature to obtain a clear solution. This solution was then charged drop wise to the clear solution of 3-trifluoromethyl-4-chloroaniline (5 g, 0.025 mol) in acetic acid (25 ml) at 40° C.-45° C. within 1-2 hours. The reaction mass was agitated for whole day and cooled gradually to room temperature. The obtained solid was filtered washed with water and vacuum dried at 50° C. to afford the desired product (5.8 g), i.e., 1-(4-chloro-3-(trifluoromethyl)phenyl)urea.

1. customto obtain a clear solution
2. filtrationThe obtained solid was filtered
3. washwashed with water and vacuum
4. customdried at 50° C.