HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-[2-Chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-[2-(5-Ethyl-2-pyridinyl)-2-hydroxyethoxy]benzaldehyde | HCID 11550787 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-[2-Chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde | HCID 71379247 | 76.7% |
Reaction Steps
To a stirred solution of 5 g (0.018 mol) 4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde dissolved in chloroform was added 2.63 g (0.022 mol) thionyl chloride at 55-60° C. Reaction mixture was refluxed for 1 hr. Progress of the reaction was monitored by TLC and after completion of reaction, subsequent work-up in alkaline water yielded 4 g (75%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445685B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-f54d8bef639a423198f116f5a6f3803e |
| Source note | uspto-grants-2013_05 |