Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 73505384 | HCID 73505384 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86625170 | HCID 86625170 | — |
Reaction Steps
To 1 g (0.0023 mol) 4-[2-(5-ethyl-pyridin-2-yl)-2-tosyl-ethoxy]-benzaldehyde dissolved in 15 mL toluene was added 0.27 g (0.0023 mol) thiazolidin-2,4-dione. To this 0.21 g (0.0035 mol) acetic acid and 0.3 g (0.0035 mol) piperidine were added. Reaction mixture was refluxed at 120-130° C. for 4 hr. After completion of reaction on TLC, substantial work-up gave the titled product. Yield of the product was 0.36 g (30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08445685B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-bcc0ffc834874990ae0da61e6e2cae9e |
|---|
| Source note | uspto-grants-2013_05 |
|---|
