4-Amino-3-hydroxybutanoic acid → HCID 178525621, compound

HRID 2094846Notes

Reaction equation

HRID 2094846 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCCC)=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[NH2:33][CH2:34][CH:35]([OH:40])[CH2:36][C:37]([OH:39])=[O:38]>>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([NH:33][CH2:34][CH:35]([OH:40])[CH2:36][C:37]([OH:39])=[O:38])=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:30])([F:32])[F:31])[CH:3]=1

Participants

3

Reactant 2

HCID 21494-Amino-3-hydroxybutanoic acidHCID 672409345-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one

Product 1

HCID 178525621HCID 178525621, compound

Procedure

4-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-ylamino}-3-hydroxy-butyric acid was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one and 4-amino-3-hydroxy-butyric acid following General Procedure B.

Sources & evidence

ORD record
ord-d0a1f56ad5ca431fa4db4cd6698e9f1b
Source dataset
uspto-grants-2013_05
Patent number
US08445690B2

Reaction notes

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