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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2094847Generated: October 30, 2026

tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate → HCID 178452472, compound

https://huagongshe.com/reaction/2094847

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylateHCID 11229445—
Reactant5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-oneHCID 67240123—
ProductHCID 178452472HCID 178452472—

Reaction Steps

3-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-ylamino}-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and 3-Amino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester following General Procedure C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445690B2
Source datasetuspto-grants-2013_05
ORD IDord-c2798969a4394438bfc662cdd6e5e9c7
Source noteuspto-grants-2013_05