HRID2094850

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=Cc1ccc2c(c1)c(I)nn2Cc1ccc(C(F)(F)F)cc1C(F)(F)F

HCID86654585

未命名化合物

HCID178480895

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(CCNC2=NC(=O)C(=Cc3ccc4c(c3)c(I)nn4Cc3ccc(C(F)(F)F)cc3C(F)(F)F)S2)CC1

HCID178480894

未命名化合物

PROCEDURE

实验过程

5-[1-(2,4-Bis-trifluoromethyl-benzyl)-3-iodo-1H-indazol-5-ylmethylene]-2-[2-(4-methyl-piperazin-1-yl)-ethylamino]-thiazol-4-one was prepared from 1-(2,4-Bis-trifluoromethyl-benzyl)-3-iodo-1H-indazole-5-carbaldehyde and 2-[2-(4-Methyl-piperazin-1-yl)-ethylamino]-thiazol-4-one following General Procedure E.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-322d8adcda2842788cc5213426c87970
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08445690B2
来源说明: uspto-grants-2013_05

反应 SMILES

[F:1][C:2]([F:27])([F:26])[C:3]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[C:8]([I:17])=[N:7]1.[CH3:28][N:29]1[CH2:34][CH2:33][N:32]([CH2:35][CH2:36][NH:37][C:38]2[S:39][CH2:40][C:41](=[O:43])[N:42]=2)[CH2:31][CH2:30]1>>[F:1][C:2]([F:26])([F:27])[C:3]1[CH:21]=[C:20]([C:22]([F:24])([F:23])[F:25])[CH:19]=[CH:18][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:40]3[S:39][C:38]([NH:37][CH2:36][CH2:35][N:32]4[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][CH2:31]4)=[N:42][C:41]3=[O:43])=[CH:12][CH:13]=2)[C:8]([I:17])=[N:7]1