HCID 871814, compound → HCID 57944939, compound

HRID 2094916Notes

Reaction equation

HRID 2094916 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1.Cl[S:21]([C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30]C)=[O:29])=[CH:26][CH:25]=1)(=[O:23])=[O:22]>>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]([CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH3:15])=[CH:12][CH:13]=1)[S:21]([C:24]1[CH:25]=[CH:26][C:27]([C:28]([OH:30])=[O:29])=[CH:32][CH:33]=1)(=[O:23])=[O:22]

Participants

3

Reactant 2

HCID 871814HCID 871814, compoundHCID 4738388Methyl 4-(Chlorosulfonyl)benzoate

Product 1

HCID 57944939HCID 57944939, compound

Procedure

Prepared as in example 5-10 from N-(3,4-difluorobenzyl)(4-methoxyphenyl)-methanamine (example 5-36a) and methyl 4-(chlorosulfonyl)benzoate (example 5-10c). MS (M−H, 446); 1H NMR (400 MHz, DMSO-d6): δ ppm: 3.69 (s, 3H), 4.20 (s, 4H), 6.73 (d, J=8.8 Hz, 2H), 6.93 (m, 2H), 6.98 (d, J=8.8 Hz, 2H), 7.22 (m, 1H), 7.74(d, J=8.4 Hz, 2H), 7.99 (d, J=8.4 Hz, 2H).

Sources & evidence

ORD record
ord-ef7eaeaf69864d17a91072a5e50d3875
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

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