Benzylamine → HCID 57422349, compound

HRID 2094930Notes

Reaction equation

HRID 2094930 reaction equation
Cl[S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11]C)=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.Br[CH2:24][C:25]1[CH:34]=[CH:33][C:28]([C:29]([O:31]C)=[O:30])=[CH:27][CH:26]=1>>[CH2:15]([N:22]([CH2:24][C:25]1[CH:34]=[CH:33][C:28]([C:29]([OH:31])=[O:30])=[CH:27][CH:26]=1)[S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 256687Methyl 4-(bromomethyl)benzoateHCID 4738388Methyl 4-(Chlorosulfonyl)benzoate

Product 1

HCID 57422349HCID 57422349, compound

Procedure

Prepared as in example 5-10 from methyl-4-(chlorosulfonyl)benzoate (example 5-10c), benzyl amine and methyl 4-(bromomethyl)benzoate MS (M+H, 426.10); 1H NMR (400 MHz, DMSO-d6): δ, ppm: 4.29(s, 2H), 4.34(s, 2H), 7.03(m, 2H), 7.12(m, 2H), 7.68(d, J=8 Hz, 2H), 7.94(d, J=8.8 Hz, 2H), 8.06(d, J=8.8 Hz, 2H), 13.03(s, 2H).

Sources & evidence

ORD record
ord-d83ee73e788b4cc281b2717b9b610a3d
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

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