HCID 57419852, compound → HCID 57944916, compound

HRID 2094977Notes

Reaction equation

HRID 2094977 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:12]=[C:11]([N:13]3[C:17](=[O:18])[CH2:16][NH:15][C:14]3=[O:19])[CH:10]=[N:9]2)=[C:5]([CH3:20])[O:4][N:3]=1.Br[CH2:22][C:23]1[CH:27]=[C:26]([CH3:28])[N:25]([CH3:29])[N:24]=1>>[CH3:29][N:25]1[C:26]([CH3:28])=[CH:27][C:23]([CH2:22][N:15]2[CH2:16][C:17](=[O:18])[N:13]([C:11]3[CH:10]=[N:9][N:8]([CH2:7][C:6]4[C:2]([CH3:1])=[N:3][O:4][C:5]=4[CH3:20])[CH:12]=3)[C:14]2=[O:19])=[N:24]1

Participants

3

Reactant 2

HCID 57419852HCID 57419852, compoundHCID 574224243-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione

Product 1

HCID 57944916HCID 57944916, compoundYield 22%

Procedure

Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 3-(bromomethyl)-1,5-dimethyl-1H-pyrazole. Yield: 22%. MS M+H calculated 384.1; found 384.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.3 uM

Sources & evidence

ORD record
ord-2759d509792648c39ffcdcc7cdbbf476
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

Loading…