3-(Bromomethyl)-1-methyl-1H-pyrazole → HCID 57422457, compound

HRID 2094987Notes

Reaction equation

HRID 2094987 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:12]=[C:11]([N:13]3[C:17](=[O:18])[CH2:16][NH:15][C:14]3=[O:19])[CH:10]=[N:9]2)=[C:5]([CH3:20])[O:4][N:3]=1.Br[CH2:22][C:23]1[CH:27]=[CH:26][N:25]([CH3:28])[N:24]=1>>[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:12]=[C:11]([N:13]3[C:17](=[O:18])[CH2:16][N:15]([CH2:22][C:23]4[CH:27]=[CH:26][N:25]([CH3:28])[N:24]=4)[C:14]3=[O:19])[CH:10]=[N:9]2)=[C:5]([CH3:20])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 135494393-(Bromomethyl)-1-methyl-1H-pyrazoleHCID 574224243-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione

Product 1

HCID 57422457HCID 57422457, compoundYield 19%

Procedure

Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 3-(bromomethyl)-1-methyl-1H-pyrazole. Yield 19%. MS M+H calculated 370.1; found 370. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.4 uM.

Sources & evidence

ORD record
ord-4f4b7323ea3442fa9328a01ad39d3f5f
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

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