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HRID2095013

反应详情

EQUATION

反应方程式

HRID 2095013 的结构方程式

REACTANTS

反应物

2
结构：COc1ccnc(CCl)c1OC.Cl
HCID16216928

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride

C8H11Cl2NO2

结构：Cc1noc(C)c1Cn1cc(N2C(=O)CNC2=O)cn1
HCID57422424

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccnc(CN2CC(=O)N(c3cnn(Cc4c(C)noc4C)c3)C2=O)c1OC
HCID57944923

未命名化合物

收率 26%

PROCEDURE

实验过程

Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione and 3,4-dimethoxy-2-chloromethylpyridine hydrochloride. Yield: 26%. MS M+H calculated 360.2; found 360.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 1.0 μM.