3-(t-Butyldimethylsilyloxy)benzaldehyde → HCID 59524397, compound

HRID 2095051Notes

Reaction equation

HRID 2095051 reaction equation
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:18][C:19]([CH3:26])([CH2:24][OH:25])[C:20]([O:22][CH3:23])=[O:21]>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][NH:18][C:19]([CH3:26])([CH2:24][OH:25])[C:20]([O:22][CH3:23])=[O:21])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 112071113-(t-Butyldimethylsilyloxy)benzaldehydeHCID 13221872Methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride

Product 1

HCID 59524397HCID 59524397, compoundYield 97%

Procedure

Prepare as in Example 12-9c from 3-(tert-butyldimethylsilyloxy)benzaldehyde (Example 12-1c) and methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride. Yield 97%, yellowish oil. MS 354 (MH+).

Sources & evidence

ORD record
ord-33798ed1a4f644ed9ae95b795487aac8
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

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