HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → HCID 53375153, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoxazole, 4-(chloromethyl)-3,5-dimethyl- | HCID 88246 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione | HCID 59524388 | — |
| Product | HCID 53375153 | HCID 53375153 | — |
Reaction Steps
Prepared as in Example 12-16 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione (Example 12-16a) and 4-(chloromethyl)-3,5-dimethylisoxazole. MS 413 (MH+). The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.08 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445692B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-02246198ca9945aea2ffb812df9c94a5 |
| Source note | uspto-grants-2013_05 |