HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-Fluoro-4-morpholin-4-ylmethylphenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-(2-Fluoro-4-nitrobenzyl)morpholine | HCID 21955027 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Fluoro-4-morpholin-4-ylmethylphenylamine | HCID 21955013 | 99% |
Reaction Steps
To a solution of 4-(2-fluoro-4-nitrobenzyl)morpholine (245 mg; 1.02 mmol) in THF:ethanol mixture (1:1) (40 mL) was added a catalytical amount of Raney-Nickel and hydrazine hydrate (6.0 mmol) and the mixture was stirred for 20 minutes at ambient temperature, then filtered through a Celite/silica gel pad. The filtrate was evaporated to provide the title compound (210 mg, 99%), which was used in further reactions without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445694B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-36971d73bf1b4602b3984cc267a4d933 |
| Source note | uspto-grants-2013_05 |