HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → quinazolin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 6-Nitroquinazoline | HCID 600211 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | quinazolin-6-amine | HCID 589288 | — |
Reaction Steps
SnCl2 (8.5 g) dissolved in 8.5 mL of conc. HCl was added to the solution of 6-nitroquinazoline in 42.5 mL of 6 N HCl at 0° C. The reaction mixture was neutralized with KOH 10 minutes later and then extracted with diethyl ether (Et2O) and EtOAc. The product 6-aminoquinazoline was obtained (0.67 g) after the removal of the solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445694B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c28f91cc0c7247d8b3fb3eb3b67f240b |
| Source note | uspto-grants-2013_05 |