Hydrochloric Acid → HCID 178434098, compound

Participants

Reaction Steps

3-[N′-(3-amino-5-methylpyrazol-4-ylidene)hydrazino]-1H-pyrazole-4-carboxylic acid was prepared by dissolving 3-[N′-(3-amino-5-methylpyrazol-4-ylidene)hydrazino]-1H-pyrazole-4-carboxylic acid ethyl ester (0.2 g, 0.8 mmol) in ethanol containing sodium hydroxide (0.2 g, 5 mmol) and the solution was stirred overnight. The mixture was then acidified to pH 1 with 1N hydrochloric acid and the resulting solid was isolated by filtration. The crude material was purified by preparative TLC eluting with (CHCl3:MeOH:H2O=4:1:0.005) to yield 39 mg (22%) of the compound as a red solid.

Provenance & Evidence