HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-(Morpholin-4-ylmethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-(3-Nitrobenzyl)morpholine | HCID 783231 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | 3-(Morpholin-4-ylmethyl)aniline | HCID 1096406 | 117.3% |
Reaction Steps
To a solution of 4-(3-nitrobenzyl)morpholine (2.0 g; 9.0 mmol) in THF/ethanol mixture (1:1, 50 mL) was added a catalytical amount of Raney-Ni and hydrazine hydrate (36.0 mmol) and the mixture was stirred for 15 min at ambient temperature, filtered through a celite pad and the filtrate was evaporated to provide pure 3-morpholin-4-ylmethylphenylamine (2.03 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445694B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-fa38d7045d384f418703e8c77980cec8 |
| Source note | uspto-grants-2013_05 |