HCID 56951230, compound → HCID 68612212, compound

HRID 2095301Notes

Reaction equation

C(OC1C=C([C@@H]2C[C@H]2CO)C=NC=1)C1C=CC=CC=1.[C:20]([O:24][C:25]([N:27]1[CH2:30][CH2:29][C@H:28]1[CH2:31][O:32][C:33]1[CH:34]=[C:35]([C@H:39]2[CH2:41][C@@H:40]2[CH2:42][OH:43])[CH:36]=[N:37][CH:38]=1)=[O:26])([CH3:23])([CH3:22])[CH3:21].C(OC1C=C([C@H]2C[C@@H]2CO)C=NC=1)C1C=CC=CC=1>>[C:20]([O:24][C:25]([N:27]1[CH2:30][CH2:29][C@H:28]1[CH2:31][O:32][C:33]1[CH:34]=[C:35]([C@@H:39]2[CH2:41][C@H:40]2[CH2:42][OH:43])[CH:36]=[N:37][CH:38]=1)=[O:26])([CH3:23])([CH3:22])[CH3:21]

Participants

Reactant 3

HCID 56951230HCID 56951230, compound

HCID 56951231HCID 56951231, compound

HCID 68613216HCID 68613216, compound

Product 1

HCID 68612212HCID 68612212, compound

Procedure

This compound is prepared from (1R,2R)-2-[5-(benzyloxy)-3-pyridyl]cyclopropylmethanol in the same manner as its diastereoisomer, (1S,2S)-2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]cyclopropylmethanol, is prepared in Example 1 from (1S,2S)-2-[5-(benzyloxy)-3-pyridyl]cyclopropylmethanol.

Sources & evidence

ORD record: ord-cd61a8d25d30477ea0c9a3af3d4de6d4
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445684B2

Reaction notes

Loading…