HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Iodo-A-85380, 5-trimethylstannyl N-boc derivative → 3-[5-[[1-(tert-Butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]-5-fluorocinnamic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Iodo-A-85380, 5-trimethylstannyl N-boc derivative | HCID 10574471 | — |
| Reactant | 3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-1-propanol | HCID 59371531 | — |
| Reactant | 3-Fluoro-5-iodocinnamic Acid Methyl Ester | HCID 67309546 | — |
| Product | 3-[5-[[1-(tert-Butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]-5-fluorocinnamic Acid Methyl Ester | HCID 68611541 | — |
Reaction Steps
This compound is prepared by Stille coupling of 3-fluoro-5-iodocinnamic acid methyl ester and 3-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-5-(trimethylstannyl)pyridine, using the same procedure as described above for the preparation of 3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-1-propanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445684B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c4c7ba6c0dcc4c7a87b7450f05ae8fe8 |
| Source note | uspto-grants-2013_05 |