Nitrogen → HCID 59371503, compound

Participants

Reaction Steps

To a solution of benzyl 3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propylcarbamate (71.1 mg, 134 μmol) in methanol (3 mL) was added 10% Pd/C (26 mg). The mixture was stirred magnetically under a H2 atmosphere (balloon) at room temperature for 130 min. H2 was replaced by N2, and the catalyst was removed by filtration over a cotton plug. The solution was evaporated and dried (30° C./oil pump vacuum) to yield 47.3 mg (89%) of a colorless film. MS (EI) m/z 397(M+, 4.3%), 341 (4.3%), 311 (17%), 242 (18%), 241 (25%), 198 (10%), 100 (12%), 70 (14%), 57 (100%), 56 (73%).

Provenance & Evidence